Download Biotechnology in China I: From Bioreaction to Bioseparation by Hui-Lei Yu, Jian-He Xu, Wen-Ya Lu, Guo-Qiang Lin (auth.), PDF

By Hui-Lei Yu, Jian-He Xu, Wen-Ya Lu, Guo-Qiang Lin (auth.), Jian-Jiang Zhong, Feng-Wu Bai, Wei Zhang (eds.)

In contemporary years, biotechnology learn and improvement (R&D) in China has been receiving expanding consciousness from the realm. With the open-door coverage of the chinese language govt, many foreign guides (for academia) and massive industry strength (for undefined) represent the 2 gigantic purposes for the above phen- enon. Biotechnology has turn into one of many priorities in Mainland China for therefore- ing many vital difficulties, comparable to meals offer, future health care, surroundings defense, or even strength. The critical executive has been enforcing a c- ple of courses which hide a large spectrum in easy examine, high-tech devel- ment and industrialization, corresponding to easy examine software (973 Plan), Hi-Tech R&D software (863 Plan), Key technology & expertise challenge fixing software (Gong-guan Plan), in addition to the institution of facilities of excellence - Key Laboratories and Engineering facilities, and so on. The investment from a number of neighborhood gove- ments and for R&D has additionally been expanding consistently. Biotechnology facilities in Shenzhen, Shanghai and Beijing were demonstrated. There are greater than four hundred universities, learn institutes and corporations and a complete of over 20,000 researchers all for biotechnology within the Mainland. The variety of examine papers released across the world and patent purposes is additionally expanding quickly. furthermore, the massive industry strength with approximately 1. four billion inhabitants, that is already open to the surface international, has supplied quite a few possibilities for int- nationwide and household businesses to take a position in biotechnology, which pushes ahead the biotechnology industrialization in China.

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Extra info for Biotechnology in China I: From Bioreaction to Bioseparation and Bioremediation

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Li et al. [140, 141] isolated a strain of A. niger CGMCC 0496, which has high stereoselectivity toward ortho- or para-substituted styrene-oxides. Zheng et al. [142] cloned, sequenced and expressed an epoxide hydrolase gene from Rhodococcus opacus in E. coli. This epoxide hydrolase showed a high stereospecificity for l(+)tartaric acid, but not for d (–) tartaric acid. C. C. 84, a Lyase) Nitriles are an important type of synthetic intermediates in organic synthesis, because of their easy preparations and versatile transformations.

Wang MX (2005) Top Catal 35:117 149. Martinkova L, Kren V (2002) Biocatal Biotrans 20:73 150. Cowan DA, Cameron RA, Tsekoa TL (2003) Adv Appl Microbiol 52:123 151. Huang W, Jia J, Cummings J, Nelson M, Schneider G, Lindvist Y (1997) Structure 5:691 152. Nagashima S, Nakasako M, Dohmae N, Tsujimura M, Takio K, Odeka M, Yohda M, Kamiya N, Endo I (1998) Nat Struct Biol 5:347 153. Miyanaga A, Fushinobu S, Ito K, Wakagi T (2001) Biochem Biophy Res Commun 288:1169 154. Wang MX, Lu G, Ji GJ, Huang ZT, Meth Cohn O, Colby J (2000) Tetrahedron: Asymmetry 11:1123 155.

These enzymes operate either by direct hydrolysis of nitrile to the corresponding acid (by a nitrilase enzyme) or by sequential action of an enzyme that hydrates the nitrile to the amide and the latter is transformed to the acid (by an amidase enzyme) (Scheme 1) [7, 8]. To date, various nitrile-amide converting organisms isolated from bacteria, fungi and plant have been described [9, 10]. Among them, most of them have been derived from bacterial species by enrichment strategies with nitriles as the sole nitrogen source [11].

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