By Lokesh Bhattacharyya, Jeffrey S. Rohrer
This can be a finished resource of knowledge at the program of ion chromatography (IC) within the research of pharmaceutical medicinal drugs and biologicals. This e-book, with participants from academia, pharma, the biotech undefined, and tool production, provides the several views, event, and services of the idea leaders of IC in a finished demeanour. It explores strength IC purposes in numerous facets of product improvement and qc checking out. additionally, an appendix part offers info on serious actual and chromatographic parameters with regards to IC and data on present brands of IC structures, columns, and different components.Content:
Chapter 1 Ion Chromatography—Principles and purposes (pages 1–21): Lokesh Bhattacharyya
Chapter 2 Retention methods in Ion?Exclusion Chromatography: a brand new point of view (pages 23–47): Milko Novic and Paul R. Haddad
Chapter three Pulsed Electrochemical Detection in Ion Chromatography (pages 49–90): William R. Lacourse
Chapter four Suppressor layout and Detection for Ion Chromatography (pages 91–105): Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin and Christopher Pohl
Chapter five Modelling and Optimization of Ion Chromatographic Separations of Pharmaceutically suitable natural Ions (pages 107–133): Philip Zakaria, Greg Dicinoski, Melissa Hanna?Brown and Paul R. Haddad
Chapter 6 Ion Chromatography in Pharmaceutical Drug research (pages 135–157): Lokesh Bhattacharyya
Chapter 7 research for Impurities by way of Ion Chromatography (pages 159–174): Shreekant V. Karmarkar
Chapter eight Ion Chromatography research of Aminoglycoside Antibiotics (pages 175–192): Valoran P. Hanko and Jeffrey S. Rohrer
Chapter nine Use of Cation?Exchange Ion Chromatography within the research of prescribed drugs (pages 193–220): Christopher Pohl, Maria Rey and Rosanne Slingsby
Chapter eleven excessive functionality Ion Chromatographic research of Cholinergic Compounds: Carbachol and Bethanechol, and linked Degradation items (pages 237–245): David Trowbridge
Chapter 12 Ion Chromatographic research of prescribed drugs for Authenticity and Adulteration (pages 247–257): David S. Jackson
Chapter thirteen Ion Chromatography of Drug Product Counter?Ions and different Ions in Drug items (pages 259–269): Brian M. De Borba and Jeffrey S. Rohrer
Chapter 14 pattern guidance suggestions in Ion Chromatography for Pharmaceutical purposes (pages 271–283): Jay Gandhi
Chapter 15 Validation of Ion Chromatographic tools (pages 285–308): Shreekant V. Karmarkar
Chapter sixteen Pharmacopeial functions of Ion Chromatography (pages 309–320): Ravi Ravichandran
Chapter 10 complete methods for dimension of energetic Pharmaceutical components, Counter?Ions, and Excipients utilizing HPLC with Charged Aerosol Detection (pages 221–236): Christopher Crafts, Bruce Bailey, Paul Gamache, Xiaodong Liu and Ian Acworth
Chapter 17 Glycan research through excessive functionality Anion trade Chromatography with Pulsed Amperometric Detection (pages 321–338): Lokesh Bhattacharyya
Chapter 18 Monosaccharide research of Glycoproteins through High?Performance Anion?Exchange Chromatography with Pulsed Amperometric Detection (pages 339–350): Jeffrey S. Rohrer
Chapter 19 Two?Dimensional Ion Chromatography for Simultaneous selection of Amino Acids and Carbohydrates (pages 351–364): Petr Jandik and Jun Cheng
Chapter 20 tracking Protein N?Glycosylation Consistency utilizing HPAEC?PAD (pages 365–377): Carl Grey
Chapter 21 Oligosaccharide research by way of High?Performance Anion?Exchange Chromatography Hyphenated to built-in Pulsed Amperometric Detection and On?Line Ion?Trap Mass Spectrometry (pages 379–391): Cees Bruggink
Chapter 22 purposes of Ion Chromatography in organic Product Analyses (pages 393–421): Alfred V. Del Grosso and Brandon Duong
Chapter 23 excessive functionality Anion?Exchange Chromatography with Pulsed Amperometric Detection (HPAEC?PAD) research of GBS Glycoconjugate Vaccines: From Fermentation to ultimate Product (pages 423–434): Stefano Ricci, Barbara Fabbri, Sara Giannini, Silvia Bernardini, Marcello Morelli and Sandro D'Ascenzi
Chapter 24 balance reports and Characterization of Meningococcal A, C, Y, and W135 Glycoconjugate Vaccine (pages 435–447): Valeria Carinci, Alberto Bernardini, Cristiana Campa, Claudia Magagnoli, Francesca Beccai and Sandro D'Ascenzi
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Additional info for Applications of Ion Chromatography for Pharmaceutical and Biological Products
3 PULSED ELECTROCHEMICAL DETECTION IN ION CHROMATOGRAPHY William R. 1 INTRODUCTION The ﬁrst commercial electrochemical detector (EC) for high performance liquid chromatography (HPLC) was introduced in 1974, and over the past several decades its popularity, breadth, and application have grown signiﬁcantly. The reasons for its success can be directly attributed to its high sensitivity, often high selectivity, and wide linear range. Also, EC detectors are fairly simple in construction, relatively inexpensive, and rugged.
Chromatogr. Sci. 1998;36(4):179–186. 3. Iwinski G, Jenke DR. Determination of alcohols in pharmaceuticals by ion-exclusion chromatography, J. Chromatogr. A 1987;392:397–405 4. Warnock M, Nair L, Sadain S, Jenke DR. Evaluation of an ion exclusion/direct conductivity method for quantitating acetic and lactic acids in pharmaceutical LVP base formulations. J. Liq. Chromatogr. 2002;25(4):541–560. 5. Allan GA, Gedge JI, Nedderman ANR, Roffey SJ, Small HF, Webster R. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity.
H2 SO4 ), the electrolyte is present chieﬂy in the interstitial liquid, while the occluded phase tends to retain its pure water form. Because of the high concentration of negative charge and consequent high negative electrostatic potential at the outer surface of the resin bead, the presence of a pore is essential for analyte retention because it represents a zone with signiﬁcantly lower electrostatic repulsion than the outer surface of the bead. A cloud of analyte molecules carrying the same charge polarity as the functional groups on the resin can therefore move between the interstitial eluent and the occluded eluent in the pores, providing a basic retention process.
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